Nanocomposite of MCM-41/Fe3O4/Au for application in hyperthermia

Reference Presenter Authors
02-013 Isabela Barreto da Costa Januário Januário, I.B.(Centro De Desenvolvimento da Tecnologia Nuclear); Sousa, E.M.(Centro de Desenvolvimento da Tecnologia Nuclear); Macedo, W.A.(Centro de Desenvolvimento da Tecnologia Nuclear); Hneda, M.L.(Centro de Desenvolvimento da Tecnologia Nuclear);
Mesoporous silica nanoparticles have been considered an excellent material for biomedical applications due to their biocompatibility, low toxicity and high surface area [1]. This material can be used as support for other materials with different properties, such as magnetic or optical particles. Magnetite nanoparticles can generate heat when subjected to alternating magnetic fields, acting as a generator of hyperthermia, more specifically named magnetohyperthermia, capable of destroying the tumor tissue at temperatures ranging from 41°C to 43°C [2]. In addition to being biocompatible, gold nanoparticles have the property of generating hyperthermia when stimulated by laser, called photohyperthermia, and also capable of destroying tumor tissue [3]. The association of these particles to the silica carrier gives the final material promising properties for medical applications, such as the treatment of cancer. The objective of this work is to synthesize and characterize the material proposed aiming its use as a generator of hyperthermia for the treatment of cancer. The method consists of introducing in situ magnetite and gold nanoparticles during MCM-41 synthesis. The nanoparticles of magnetite were synthesized by co-precipitation and the gold nanoparticles through seed and growth solutions. The nanocomposites were characterized by thermogravimetric analysis (TG), fourier transform infrared spectroscopy (FTIR), ultraviolet visible spectroscopy (UV), x-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta potential, nitrogen adsorption (BET), Mössbauer spectroscopy and magnetic measurements (VSM). The heat generation capacity of the nanocomposite was quantified through temperature measurements in a magnetic induction hyperthermia chamber. Measurements of the heating property under alternating magnetic field showed that the material presents potentiality as hyperthermia agents for biological applications.
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