153Sm and 159Gd Doping Boron Nitride Nanotubes: potential application in nanomedicine

Reference Presenter Authors
02-015 Marcelo Fernandes Cipreste da Silva, W.M.(Nuclear Technology Development Center); Coco, A.M.(Nuclear Technology Development Center); Cipreste, M.F.(Nuclear Technology Development Center); Ferreira, G.A.(Nuclear Technology Development Center); Sousa, E.M.(Centro de Desenvolvimento da Tecnologia Nuclear); The technological interest for nanomaterials is directly related to the peculiar characteristics that they present in a scale of manipulation, where the dimensions are of the order of nanometers. This is the case of nanotechnology, which in its nanoscale has been influencing diverse fields of the scientific environment, among the most commonly highlighted, that of medicine. In this sense, nanomedicine emerged as a new tool to leverage the advances of applications of nanomaterials in traditional medicine. The use of nanomaterials in medicine means that traditional instrumentation and methodologies of analysis are improved with each new discovery. Therefore, the use of diagnostic and therapy techniques based on nanoparticles offers a high sensitivity, as in the case of the diagnosis of stage cancers. In this context, boron nitride nanotubes (BNNTs) stand out for their significant characteristics, such as high oxidation resistance, excellent thermal conductivity, high modulus of elasticity, piezoelectricity and an ability to suppress radiation from thermal neutrons. Besides these properties, the possibility of incorporating various types of molecules and rare-earth elements on its surface gives it additional properties. In this study, doping process of BNNTs was performed by the reduction of samarium (Sm2O3) and gadolinium (Gd2O3) oxides in the presence of hydrogen gas at high temperatures. It was performed a wide characterization of the starting materials and cell viability in vitro tests with normal human fibroblast and human primary osteogenic sarcoma (SAOS) cells before and after activation by thermal neutrons in nuclear reactor. Both systems showed great potential for application as teranostics. 

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