Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Reference Presenter Authors
02-020 Rafaela Caroline Rodrigues dos Apostolos Andrade, G.F.(Centro de Desenvolvimento da Tecnologia Nuclear); Apostolos, R.C.(Centro de Desenvolvimento da Tecnologia Nuclear); Silva, W.M.(Centro de Desenvolvimento da Tecnologia Nuclear); Sousa, E.M.(Centro de Desenvolvimento da Tecnologia Nuclear);
The impact of diseases such as cancer related of bone tissue in developed and developing countries has grown significantly in the last decades. In order to minimize the adverse effects of chemotherapy, usual for treating cancer, several studies have been conducted aiming for developing new selective ways of applying drugs selectively in the tumor cells. In recent years, intense research has focused on the development of nanostructured systems capable of incorporate molecules for treatment of cancers. The aim of this work was the production of mesoporous silica/hydroxyapatite-based nanocomposite functionalized with sensitive pH polymer, methacrylic acid (MAA). Functionalization was performed using the microwave method in order to anchor the cross-linking, tetraethylene glycol dimethacrylate (TEGDMA), on the nanoparticles surface followed by MAA polymerization. The materials were characterized by small angle X-ray scattering, X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, thermal analysis, zeta potential and elemental analysis. Studies of the incorporation and release of the antitumor methotrexate drug were performed in order to evaluate the potential use of these drug carrier systems in cancer therapy. The results indicate that the nanocomposites can be facile produced. Moreover, it was possible to study the incorporation and release of methotrexate. In conclusion, data from this work show that the nanocomposites obtained have adequate characteristic to be used as drug delivery platform.

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