Hydroxyapatite-Niobium Oxide 3D Scaffolds: Synthesis and Characterization

Reference Presenter Authors
17-022 Taiana Gabriela Moretti Bonadio Bonadio, T.G.(Unicentro); Freitas, V.F.(Universidade Estadual do Centro-Oeste); SANTOS, I.A.(Universidade Estadual de Maringá); Miyahara, R.Y.(Universidade Estadual do Centro-Oeste); Baesso, M.L.(UEM); Weinand, W.R.(UEM); Hernandes, L.(UEM); 3D Scaffolds of nanostructured hydroxyapatite and niobium pentoxide are being proposed as a new alternative to bone replacement. The composite in eutectic composition was sintered in 1080 °C. After the sintering process, three new crystalline phases was formed: PNb9O25, Ca3(PO4)2 and CaNb2O6. The composite has mechanical properties (Vickers hardness and compressive strength) much higher than in pure hydroxyapatite. In vivo tests were performed in critical size defects in rat calvaria. Microscopy analysis shown several areas of direct contact between the composite and the neo formed bone. Furthermore, the pores between 100 and 200 ?m facilitated permeation of blood vessels and the formation of bone matrix within the material showing that it is a promising candidate as a bone substitute.
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