Bioactivity of 2Na2O.1CaO.3SiO2 glass with K, Sr and P additions

Reference Presenter Authors
10-010 Karen Cristiane Ribeiro Ribeiro, K.C.(State University of de Ponta Grossa); Dechandt, I.J.(State University of de Ponta Grossa); Souza, G.B.(State University of de Ponta Grossa); Serbena, F.C.(State University of Ponta Grossa); Bioactive glasses are important in several biomedical and dental applications. The composition 2Na2O.1CaO.3SiO2 (2N1C3S) is one of the few glass systems that presents homogeneous volume crystallization and also its composition is close to 45S5 glass, one of the most bioactive materials. In this work, we study the bioactivity of the 2N1C3S glass with additions of P2O5, K2O and SrO. Phosphorus helps the formation of hydroxyapatite on the surface of the glass by ion exchange of P-3 with Ca+2 ions. The addition of K+1 avoids glass crystallization and improves bioactivity. Sr-2 increases the formation of apatite on the surface of the sample, allowing better osteoblast proliferation. An earlier study by Acevedo [1] revealed that the addition of K+P and Sr+P in this glass system promoted dentin permeability reduction for dental applications. In this study, we investigate the bioactivity of these glasses by studying the hydroxyapatite (HA) formation by immersion in simulated body fluid (SBF). The presence of HA was investigated by Fourier transform infrared spectroscopy as a function of immersion time. Samples were also characterized by differential scanning calorimetry and X-ray diffraction. The K addition increases 10oC in Tg while Sr did not change it when compared with the Tg of the 2N1C3S glass. The addition of both Sr and K caused a decrease in Tg of 20oC. The onset of the crystallization peak was increased by 120oC with K addition when compared to that of the 2N1C3S glass. The addition of Sr also increased the onset temperature by 60oC. The addition of Sr+K did not change the onset of the crystallization temperature. SBF immersion tests for these glasses did not show any formation of HA up to 30 days, but when samples containing Sr were crystallized. It revealed bioactivity between 14 and 21 days in the SBF solution immersion tests.
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