Novel zwitterionic mesoporous bioactive glasses as powerful devices for bone regeneration

Reference Presenter Authors
02-034 Sonia Fiorilli Fiorilli, S.(Politecnico di Torino); Bari, A.(Politecnico di Torino); Peretti, E.(Politecnico di Torino); Vitale Brovarone, C.(Politecnico di Torino); The effective treatment of bone fractures, especially when the natural remodelling process is compromised, still represents a challenging clinical issue. In addition, for these critical clinical situations, the risk of bacterial infections is an important obstacle for a successful therapy. To address this challenge, the design of advanced biomaterials based on bioactive mesoporous glasses (MBGs) able to synergistically combine the effects of therapeutic ions with a dual antibacterial potential would represent a big step towards novel therapies. In particular, the therapeutic ions will impart a high bioactivity and will exert pro-osteogenesis and pro-angiogenesis effects. A dual antibacterial potential can be obtained by providing MBGs with anti-adhesive properties, that will prevent bacteria attachment and colonization, and through the release of bactericidal agents (ions or/and drugs). Among the possible strategies to produce anti-adhesive surfaces, zwitterionization of biomaterials, (e.g introduction of an equal number of surface positively and negatively charged moieties), represents a promising and versatile method [1]. In this contribution, SiO2-CaO based MBGs containing different ions (Cu2+, Sr2+, Ag+) were prepared both by sol–gel (SG) by aerosol-based spray-drying (SD) process, to obtain spherical nano- and micro-sized particles, respectively. The structural and morphological features were investigated by several techniques (TEM, FE-SEM, N2 adsorption-desorption), as well as their ability to form hydroxyapatite in vitro and to release therapeutic ions. With the aim to provide MBG surfaces with ion pairs, two functionalization routes were explored: the first based on silane chemistry to graft primary/secondary amines to surface -OH groups and the second involving the anchoring of amino acid molecules. Successfull functionalization was assessed by FT-IR and zeta potential analysis. [1] Isabel Izquierdo-Barba, Acta Biomaterialia 40(2016)201
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