Orthophosphate silica nanocomposite as a bioactive material for medical application

Reference Presenter Authors
02-059 Mateusz Dulski Dulski, M.(University of Silesia); Dudek, K.(Institute of Ceramics and Building Materials); Chalon, D.(University of Silesia); Goryczka, T.(University of Silesia); Kubacki, J.(University of Silesia); Sulowicz, S.(University of Silesia); Mrozek-Wilczkiewicz, A.(University of Silesia); Metallic alloys due to their good mechanical properties, or biocompatibility are commonly used as a short-term implant. Unfortunately, due to body fluid conditions, such materials are subjected to a metal ion (Ni, V, Cr etc.) releasing into surrounding tissues which limits their application. Hence, it is still looking for a new route of surface modification, especially by using bioactive materials like ceramic phosphates (CaP) or silica glasses (SG). CaP ensures osseointegration but possess low adhesion and high fragility while SG implies formation of chemical bonds between various materials. CaP and SG can be easily modified by nanosilver providing a bactericide features of the final composite, given at the same time an opportunity to functionalize the metallic surface through the fabrication of a new type of bioactive coatings. Ag/SiO2 nanoparticles synthesized by chemical synthesis method has been mixed with tricalcium phosphate (TCP) and ethanol to prepare a triphasic inorganic colloidal suspension. The most optimal electrophoretic deposition parameters have been applied to manufacture hybrid coatings functionalized the surface of metallic implant substrate. As a result of surface functionalization, the SEM+EDS showed individual silver particles, as well as silver-silica and silver-silica-CaP agglomeration located between areas, consist of pure TCP particles. Structural Raman data have revealed presence crystalline orthophosphates and atypical glass layer composed of the Ag/SiO2/CaP with relatively low thickness formed on the stage of material preparation and sonochemical effect. Raman and XPS have shown strong interaction between composite components. Diffraction data have confirmed amorphous phase as well as reveal crystalline silver and various type of CaP. Finally, the newly prepared coating with a thickness of 50-100 nm has been determined as a possessed bactericidal feature (E. coli), stimulating at the same time proliferation of the NHDF human fibroblast.
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