Preparation and investigation of magnetic properties of nano-sized garnets for application in magnetic hyperthermia.

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(Institution)
Abstract
08-105 Barbara Sartorelli Caldeira Caldeira, B.S.(São Paulo State University); Simões, A.Z.(São Paulo State University); Longo, E.(Federal University of São Carlos); Garcia, F.G.(Federal University of Itajubá); Hepatocarcinoma is a very common type of primary liver cancer. Despite recent advances in diagnosis and new treatment options, its prognosis has poor outcomes. Only 10–20% of hepatocellular carcinomas can be removed surgically. If cancer cannot be completely removed, the disease is usually deadly within 3 to 6 months. As an alternative to the traditional treatment methods, magnetohyperthermia is now gaining more attention than ever. Magnetohyperthermia may be described as a heat generation in the tumor region through the application of magnetic nanoparticles subjected to an alternating magnetic field. The proposal of this study was to obtain magnetic nanoparticles of pure ${\mathrm{Y}}_{3}{\mathrm{Fe}}_{3,35}{\mathrm{Al}}_{1,65}{\mathrm{O}}_{12}$ crystals (garnet structure) for magnetohyperthermia application. Parameters as composition, temperature and predefined preparation time were analyzed. The material was processed applying the microwave hydrothermal synthesis method at 140°C for 30 min and then at 700°C for 2h. By the use of field emission scanning electron microscopes (FE-SEM), X-ray diffraction (XRD) and hysteresis loop, it was verified a nanocrystalline spherical compound with superparamagnetic behavior. Finally, it was observed that crystallinity influences the magnetic properties and this will be studied in future works.
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