Novel bioactive ceramic and glass-ceramic compositions for bone regeneration

Reference Presenter Authors
02-070 Ilaria Cacciotti Cacciotti, I.(University of Rome Niccolò Cusano); A noteworthy increment in the incidence of bone injuries and diseases has been evidenced, owing to the population ageing. Bone tissue engineering is considered a promising alternative to the current clinical treatments (autografts, allografts and xenografts), which still present several limitations (limited supply, secondary surgery, donor site morbidity, infection risk, recurrent pain). Bioactive ceramics and glass-ceramics are widely used for bone tissue regeneration. In details, calcium phosphates (CaPs) doped with several vicarious ions (e.g. Si4+, F-, Mg2+, Sr2+) were produced in order to simulate the chemical composition of the inorganic component of the bone extracellular matrix [2]. Furthermore, bioactive glasses have been proposed as an alternative, due to their good bioactivity, osteoinductive behaviour, ability to strongly bond to hard tissue as well as to soft tissue [1, 3-5]. It has also been reported that their ionic dissolution products are able to promote the expression of several osteoblastic cell genes, to induce angiogenesis in vitro and in vivo and to play antibacterial and in?ammatory actions [5]. Thus, substituted CaPs and innovative BG compositions were synthesised by wet precipitation and sol-gel process, respectively. The influence of the followed synthesis process, dopant ions incorporation, calcination conditions is investigated. The suitability of the produced powders for application in bone regeneration was evaluated, exploiting different potential applications: as fillers within polymeric matrices, as porous scaffolds and as bioactive coatings. [1] V. Mourino, A.R. Boccaccini, J.R.Soc. Interface 7(2010) 209. [2] I. Cacciotti, Cationic and Anionic substitutions in hydroxyapatite, In: Handbook of Bioceramics and Biocomposites, I.V. Antoniac Editor, Springer (2016) 145. [3] I. Cacciotti, J Mater Sci 52(2017) 8812. [4] I. Cacciotti et al., J. Mater. Sci. Mater. Med. 23(2012) 1849. [5] L.L. Hench, J. Europ Ceram Soc 29(2009)1257.
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