Synthesis of strontium-containing bioactive glass submicron particles using a rapid route for biomedical applications

Reference Presenter Authors
02-076 Layla Mosqueira Mosqueira, L.(Universidade Federal de Minas Gerais); Pereira, M.d.(Universidade Federal de Minas Gerais); Serakides, R.(Universidade Federal de Minas Gerais); In the field of bone regeneration and drug delivery, there is a great interest for materials that can be injectable and provide controlled delivery. It is known that the morphology and size can affect these properties and spherical particles in the nano-size range possess suitable characteristics for use in the regeneration of bone tissues. Among the materials used for this purpose, bioactive glasses (BG) are promising because of their known ability to bind tightly to the tissue and promote bone growth during implantation in vivo. Many approaches have been investigated through the incorporation of several metal ions in the network of BG in order to increase their bioactivity. Among the therapeutic ions used, strontium (Sr) ions are known to have the potential to prevent bone loss and to increase bone formation. Thus, the combination of the properties of the glass with those of Sr results in a superior material for the regeneration of tissue. Sol–gel technology has great versatility, allowing the preparation of BG with various compositions, sizes, morphologies and a large surface area that could provide improved cellular responses and enhanced bioactivity when compared to melt-derived glasses. Strontium (Sr) doped mesoporous bioactive glasses (smBG) submicron particles were successfully synthesized by a facile sol-gel method using cetyl trimethyl ammonium bromide (CTAB) as the template and a reference sample with no Sr content was produced (smBG) for comparison. The results show that Sr-containing BG particles had a spherical morphology, presents an amorphous character, high surface area and mesoporous structure. In addition, the cytotoxicity analysis using MTT indicates that the materials are non-cytotoxic at the tested concentrations, suggesting their safety for biomedical applications when used in suitable concentrations, and Sr-containing submicron spherical particles are a potential candidate for application in bone tissue engineering.
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