Strategies for surface functionalization of sol-gel derived bioactive glasses grafted with functional organosilane groups

Reference Presenter Authors
(Institution)
Abstract
02-078 Marina Almeida Santos de Nardi Nardi, M.A.(Federal University of Abc); Seabra, A.B.(Federal University of Abc); Borges, R.(Federal University of Abc); Marchi, J.(Federal University of Abc); One therapeutic strategy for bone regeneration is the use of synthetic biomaterials, such as calcium phosphate and bioactive glasses. Both materials present osteoconductive and osteoinductive properties due to the interaction with body fluid, promoting ion exchange reactions in the material-tissue interface which results in hydroxyapatite nucleation. Besides calcium and phosphorous, bioactive glasses contain silicon atoms in its structure, favoring the silanol (Si-OH) bond formation. These functional groups can be bonded to organosilane groups such as 3-aminopropyl-triethoxysilane (APTES) and 3-mercaptopropyl-trimethoxysilane (MPTMS), which can be successfully used to immobilize functional biomolecules that, in turns, favors bone regeneration by providing an appropriate environment. In this work, we present some strategies to improve the surface functionalization of bioactive glasses. These materials were based on the SiO2-CaO-P2O5 system and were produced through quick alkali sol-gel method. Surface functionalization of bioactive glass was performed after cleaning the glass surface with ultrapure water and acetone in order to increase the silanol group population. Non-cleaned surface glasses were produced as control. Both cleaned and non-cleaned glasses were then functionalized using APTES and MPTMS under reflux in toluene. The functionalized materials were characterized by FTIR, XPS and BET. The effectiveness of the functionalization was confirmed by the presence of amino and thiol groups on the material surface, respectively for APTES and MPTMS samples. The specific surface area increased after the functionalization in relation to the pure bioglass, suggesting the success of the functionalization. The cleaning step enhanced the population of functional groups of both organosilanes. The overall results suggested as a successfully strategy in order to produce functionalized bioactive glasses.
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