In vitro biological characterization of biocompatible glasses based on SiO2-CaO-P2O5-AgO system

Reference Presenter Authors
02-082 Juliana Marchi Mendes, A.P.(SENAI); Marchi, J.(Universidade Federal do ABC, Campus Santo André); Rigo, E.C.(Universidade de São Paulo, Campus Pirassununga); Santos Jr, A.R.(Universidade Federal do ABC, Campus Santo André); Pugine, S.M.(Universidade de São Paulo, Campus Pirassununga); Biocompatible glass can be used as biomaterial for bone regeneration because of its ability to nucleate hydroxyapatite in a host tissue. One of the main complications for the bone tissue recovery is the action of bacterial infection. Silver is an important bactericidal agent for the treatment of bone tissue infection. Thus, in this paper, silver was incorporated in different amounts (1, 5 and 10 wt%) in the biocompatible glass based on SiO2-CaO-P2O5 system . The samples were obtained by sol-gel synthesis, and then lyophilized and calcined at 550° C. The obtained powders were biologically characterized by the determination of minimum inhibitory concentration, minimal bactericidal concentration and cytotoxicity evaluation through indirect cell viability using MTT assay. The results of biological characterization indicated the effectiveness of the silver incorporation as antibacterial agent in the studied systems, which directly affected the toxicity of the materials. The compositions with higher silver content presented cytotoxicity. However, this effect could be controlled by diluting these compositions in carrier vehicles, thereby obtaining a promising material to be used as bone regeneration allied with bactericidal effect.
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