Development of a new sol-gel synthesis route to obtain bioactive glasses containing iron oxide phases for applications in hyperthermia

Reference Presenter Authors
02-093 Roger Borges Borges, R.(Federal University of Abc); Ferreira, L.M.(Federal University of ABC); Rettori, C.(Federal University of ABC); Marchi, J.(Federal University of Abc); Magnetic bioactive glasses have been proposed as potential materials for treatment of bone cancer. These glasses consist of a glass matrix containing a ferrimagnetic or superparamagnetic crystalline phase, which enables these glasses to display desired properties for bone regeneration and hyperthermia simultaneously. In this work, we studied a new route to produce sol-gel derived magnetic bioactive glasses, since there is a lack of knowhow about how to produce these glasses exclusively through the sol-gel method. The glass compositions were based on the SiO2-CaO-P2O5 system containing 10, 20 or 30 wt.% of Fe2O3. The glasses were produced through a modified quick-alkali sol-gel method done in two steps, calcined at 550°C, and then submitted to thermal treatment at 670°C. The obtained powders were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry analysis and VSM-SQUID magnetometer. The results evidenced that a glassy phase was obtained after calcination at 550°C, indicating that Fe2O3 content was incorporated in the glass structure. The addition of Fe2O3 in the glass structure induced a 3Q2 ? 2Q3 silicate species conversion. The thermal treatment at 670°C led to the nucleation of hematite (?-Fe2O3) and maghemite (?-Fe2O3), and the powders displayed superparamagnetic properties. In conclusion, the overall results evidenced that the new route developed in this work was able to produce bioactive glasses with superparamagnetic properties, exhibiting suitable properties for bone cancer treatment.
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